Travel Guide to A Fascinating Singapore Holiday | BeCleanLiveGreen

Posted by Travel-and-Leisure:Destination-Tips Articles from EzineArticles.com on November 23, 2012

Travel to Singapore is a remarkable experience offering you a perfect mix of nature, culture and adventures to savor. Take a package tour to this Southeast Asian city/state and wonderful moments in your memorabilia......

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Straightforward Holiday Dinner Techniques For Non-Prepares | My ...

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Extreme weather threatens US transportation

WASHINGTON (AP) ? Extreme weather is a growing threat to the nation's lifelines ? its roads, bridges, railways, airports and transit systems. That's leaving states and cities trying to come to terms with a new normal.

Superstorm Sandy is the latest and most severe example. It inflicted the worst damage to the New York subway system in its 108-year history. New York isn't alone; intense rain, historic floods and record temperatures are taking a toll on transportation across the country.

Transportation engineers build highways and bridges to last 50 or even 100 years. Now they are reconsidering how they do that.

The American Association of State Highway and Transportation Officials is weighing rewriting its standards on design, construction and maintenance of roads and bridges to reflect new weather extremes.

Source: http://news.yahoo.com/extreme-weather-threatens-us-transportation-192715153.html

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California Terror Suspects: 2 of 4 Were New Islamic Converts

UPLAND, Calif. ? Three of the young men swept up in a federal terrorism probe grew up in the Southern California suburbs where they played pick-up basketball, ran for homecoming court and sparred in video games with neighborhood kids ? a far cry from the wannabe terrorists described by the FBI.

Two of the men converted to Islam less than two years ago and the third, an American-born Vietnamese Muslim, drifted into their orbit as recently as September after a game of paintball. He also is an unemployed high school dropout and new father.

The rapid evolution from suburban teen to aspiring jihadist alleged in court documents blindsided family members, but experts who study homegrown terrorism said the case highlights the susceptibility of new converts to radicalization, particularly among the young.

Conversion to Islam requires just a single statement of faith, but the newly faithful must then choose among a universe of competing interpretations of Islam, many overtly political and easily available on the Internet.

"To convert to Islam you just have to make one statement of faith: `There is no God but God, and Muhammad is his messenger.' But these people did that and then they feel they are Muslim," said Muhamad Ali, an assistant professor at the University of California, Riverside, and an expert in Islamic studies.

"They might pray five times a day, they might fast, but they don't see Islam in a comprehensive way. Education and understanding are critical and one of the challenges in the United States is to make sure that these converts are in the right hands."

According to court documents, the four men arrested late last week found trouble from the start.

Two of the members of what the FBI called an extremist network ? Miguel Alejandro Santana Vidriales, 21, and Ralph Deleon, 23 ? converted after meeting Sohiel Omar Kabir in an Ontario, Calif., hookah bar. The naturalized U.S. citizen from Afghanistan introduced them to the radical Islamist doctrine of the U.S.-born extremist cleric Anwar al-Awlaki, who was killed last year in an American airstrike in Yemen, according to court files unsealed this week.

Kabir, 34, later returned to Afghanistan but continued to give direction to the Southern California men on Skype. He was taken into custody last weekend.

The fourth defendant, 21-year-old Arifeen David Gojali, joined the group in September after they played paintball together to sharpen their shooting skills, according to court documents.

The father of a baby girl had moved out of his parents' home two months ago and drifted away as he fell under the sway of Deleon, who was a charismatic and popular worshipper at the mosque the two attended, Gojali's younger sister told The Associated Press.

His family didn't know of his arrest until news reports earlier this week and was shocked at what they heard, said the sister, 18, who requested anonymity because she did not want to be associated with the alleged crimes.

"What a lot of the news channels are saying is the first time I'm hearing about it and the first time my family's hearing about it," she said.

All four men are facing charges of providing material support to terrorists, which can carry a maximum 15-year prison sentence.

Authorities won't say how the investigation began, but at least two members of the group shared their beliefs on Facebook and held Skype phone calls with Kabir ? all of which was recorded by an FBI informant or captured by agents monitoring their activity.

Covert FBI agents had conversations with Santana online, where he expressed his support of jihad and desire to join al-Qaida, authorities said.

Defense attorneys for Gojali and Santana did not return calls seeking comment. Deleon's lawyer, Randolph Driggs, declined to comment about the charges against his client.

Their plans were to advance Sunday with a flight to Istanbul ? and then to Afghanistan where Kabir said he had set up meetings with terrorists ? but the men were arrested two days before. Before their departure, they had scrubbed their Facebook profiles of Islamic references and planned to leave goodbye letters and invented a cover story about attending a wedding in Afghanistan.

Despite their aspirations, the three probably weren't likely to find themselves on the front lines of a jihad any time soon, said Daveed Gartenstein-Ross, a senior fellow at the Washington, D.C.-based Foundation for Defense of Democracies, a non-partisan think tank focused on national security and foreign policy.

Recent history is cluttered with instances of radicalized Muslims from the U.S. and other Western nations who traveled to Afghanistan or Pakistan to join the jihad, only to find themselves turned away or strung along, he said. Little has been publicly released about Kabir, the alleged recruiter, but it's unlikely he would have been in a position to secure a spot for the three in any important operations, he added.

"It's quite possible these guys would have gotten the cold shoulder had they gone over there," he said. "They're not really useful guys, they're not people who have a great deal of knowledge about the U.S. that could benefit the Taliban organization, they don't have skill sets. The best things they have to offer are their passports and their ethnicity."

That's little solace for their families ? or for Muslims who worry cases like this are a symptom of a whole generation of new converts who have little in common with organized worship and the mosque communities that traditionally provide religious education and spiritual guidance.

"The imams should reach out. They have to make the mosques interesting and attractive to young generations and try to understand their psychology, try to address their concerns and have a dialogue," said Ali, the UC Riverside professor.

"They cannot just say `Islam is a religion of peace' and do nothing. To me, this is a really a challenge for imams, to really address the issue," he said. "They cannot deny it's happening, even though it's a very small minority."

___

Associated Press writer Greg Risling in Los Angeles contributed to this report.

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Source: http://www.huffingtonpost.com/2012/11/21/2-of-4-terror-suspects-we_0_n_2174237.html

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Weather, airport strikes loom as 43 million hit the road

As more than 43 million Americans gear up this morning for the busiest travel day of the year, inclement weather and airport strikes may put a damper on Thanksgiving travels for some.

Those in the Pacific Northwest will have to brace for a soggy ride, as up to 10 inches of rain fell in parts of Oregon, up to 9 inches in Washington, and 6.5 inches in Northern California. In Oregon, this was in some parts one of the top rainiest storms ever. A third storm system is moving through the West today producing more rain, but it will not be as heavy as Monday's rainfall.

Approximately 39 million of today's travelers are hitting the road by car, and motorists along the East Coast can look forward to a smooth ride, as most of the weather looks calm from New York to Atlanta, with mild with temperatures in the 50s in the Northeast and near 70 in Georgia.

Traffic, unsurprisingly, will not be quite as breezy, with family-filled cars expected to clog roads from coast to coast.

Dense fog that rolled into the Chicago last night, combined with a light wind, clearing skies and a moist air mass is now causing traffic delays across the area.

The top five cities bracing for the worst traffic today are: New York, Washington D.C, Chicago, San Francisco, and the most tangled roads will be in Los Angeles, with holiday road trips predicted to take 33 percent longer than usual.

And that's not the only headache in Los Angeles. Airport union workers are preparing to strike this morning at LAX. The workers, who are angry over terminated union contracts and eliminated health insurance, admit they could not have picked a worse day or a busier airport.

"It's a national day about being with your family and taking care of your family, and these workers are not able to do that," Andrew Gross Gaitan of the Seiu United Service Workers West said.

Job actions are not just in California ? angry workers are picketing coast-to-coast: from Chicago's O'Hare airport... to New York's JFK to Fort Lauderdale, Florida.

For those hitting the highway today, AAA recommends leaving as early as possible, and at the latest 2 .p.m., because by 5 p.m. the roads will be jam packed. Rush hour is expected to peak two hours earlier than normal.

"With today expected to be the busiest day, and many people also working, we're expecting this evening there will be a lot of congestion," AAA spokeswoman Heather Hunter said.

There is, however a silver lining for motorists, as gas prices are down 5 cents in the last two weeks, with the national average for a gallon of regular fuel topping off at $3.41.

ABC News' Max Golembo contributed to this report Also Read

Source: http://gma.yahoo.com/43m-hit-road-thanksgiving-112408592--abc-news-topstories.html

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So...what are you eating/drinking?

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Key events early in process of cellular aging defined

ScienceDaily (Nov. 21, 2012) ? For the first time, scientists at Fred Hutchinson Cancer Research Center have defined key events that take place early in the process of cellular aging. Together the discoveries, made through a series of experiments in yeast, bring unprecedented clarity to the complex cascade of events that comprise the aging process and pave the way to understanding how genetics and environmental factors like diet interact to influence lifespan, aging and age-related diseases such as cancer and neurodegenerative disorders.

The findings, including unexpected results that link aspects of aging and lifespan to a mechanism cells use to store nutrients, are described in the Nov. 21 issue of Nature by co-authors Daniel Gottschling, Ph.D., a member of the Hutchinson Center's Basic Sciences Division, and Adam Hughes, Ph.D., a postdoctoral fellow in the Gottschling Lab.

The researchers found the acidity of a structure in yeast cells known as the vacuole is critical to aging and the functioning of mitochondria -- the power plants of the cell. They also describe a novel mechanism, which may have parallels in human cells, by which calorie restriction extends lifespan.

The work began with Hughes and Gottschling searching for the source of age-related damage in mitochondria.

"Normally, mitochondria are beautiful, long tubes, but as cells get older, the mitochondria become fragmented and chunky," said Gottschling, also an affiliate professor in the Department of Genome Sciences at the University of Washington. "The changes in shape seen in aging yeast cells are also observed in certain human cells, such as neurons and pancreatic cells, and those changes have been associated with a number of age-related diseases in humans."

What causes mitochondria to become distorted and dysfunctional as cells age had long been a mystery, but Gottschling and Hughes have discovered that specific changes in the vacuole lead directly to their malfunctioning.

The vacuole -- and its counterpart in humans and other organisms, the lysosome -- has two main jobs: degrading proteins and storing molecular building blocks for the cell. To perform those jobs, the interior of the vacuole must be highly acidic.

Hughes and Gottschling found that the vacuole becomes less acidic relatively early in the yeast cell's lifespan and, critically, that the drop in acidity hinders the vacuole's ability to store certain nutrients. This, in turn, disrupts the mitochondria's energy source, causing them to break down. Conversely, when Hughes prevented the drop in vacuolar acidity, the mitochondria's function and shape were preserved and the yeast cells lived longer.

"Until now, the vacuole's role in breaking down proteins was thought to be of primary importance. We were surprised to learn it was the storage function, not protein degradation, that appears to cause mitochondrial dysfunction in aging yeast cells," Hughes said.

The unexpected discovery prompted Hughes and Gottschling to investigate the effects of calorie restriction, which is known to extend the lifespan of yeast, worms, flies and mammals, on vacuolar acidity. They found that calorie restriction -- that is, limiting the raw material cells need -- delays aging at least in part by boosting the acidity of the vacuole.

"Now that we have preliminary evidence in yeast of how calorie restriction extends lifespan, our hope is that it can be translated to higher organisms like humans," Hughes said. Given the similarities in the fundamental biology of yeast and human cells, the researchers' newly defined link between what cells "eat" and how they age could shed valuable light on the events that lead to age-related disorders in humans.

"There has been a lot in the scientific literature and the general media lately about how what you eat affects the aging process, but it has been incredibly confusing. Now we have a new paradigm for understanding how genetics and environment interact to influence lifespan, aging and age-related diseases. That's what I'm really excited about," Gottschling said.

Gottschling and Hughes speculate that if the vacuole's declining acidity limits its ability to store certain nutrients and metabolites, they may build up in the cell, flooding the mitochondria. Overwhelmed, the mitochondria use up all their energy -- essentially burning out their motors -- taking in the surplus. With no power left to import the proteins they need to maintain their elegant shape and execute their regular duties, the mitochondria literally break down. Gottschling and his colleagues are now investigating this hypothesis in detail. They are also exploring what triggers the initial drop in the vacuole's acidity.

The latter research question is of particular interest because the researchers found that even though vacuolar acidity drops as mother yeast cells age, the acidity in the vacuoles of their newborn daughter cells is normal. This corresponds to previous findings in the field that all daughter yeast cells have the same potential lifespan, regardless of the age of their mothers. The resetting of the daughter's vacuolar acidity is the earliest event yet observed in cellular rejuvenation, a phenomenon in which age-related defects are seemingly erased in an organism's offspring. This could help explain how the act of cell division itself contributes to aging.

These results are just the newest chapter in a "decade-old interest," according to Gottschling. He and his colleagues have made several landmark discoveries in the past 10 years, including finding that aging yeast cells exhibit the same genomic instability seen in human cancer cells and proving that mitochondrial dysfunction causes that instability. Gottschling's team also has developed innovative tools to leverage the power of yeast as a model organism, including a technique called the Mother Enrichment Program that makes experiments more efficient by enabling researchers to generate large populations of aging yeast cells.

"It's worth using yeast to study complex things like aging because a lot of person-years of research have gone into understanding the fundamentals. The genetic and cell-biology tools available for studying yeast are unparalleled," Gottschling said. "Having the proper tools is like having new glasses; you can see things you never could before, and once you start to see new things, you can dissect them to understand how they work."

In addition to the latest eye-popping technology, the researchers relied on sheer tenacity -- with a little help from motion-sickness pills -- in pursuit of their discoveries. Some of the painstaking experiments required Hughes to delicately manipulate individual yeast cells as they divided every two hours for days at a time. For another series of experiments that lasted several months, Hughes took Dramamine to ward off the queasiness that came with inspecting brightly colored yeast cells as they streaked across his microscope's field of view.

"There were definitely tough points, but it was worth it when we knew the story as a whole. Showing that the change in vacuolar acidity was real and that it mattered -- that it affected lifespan -- made the grueling experiments worthwhile," Hughes said. Gottschling is an elected member of the National Academy of Sciences, the American Academy of Arts & Sciences, the Washington State Academy of Sciences and the American Academy of Microbiology.

This research was funded by grants from the National Institutes of Health, the Helen Hay Whitney Foundation, a University of Washington's Genetic Approaches to Aging Training Grant and the Glenn Foundation for Medical Research. Preliminary support, including for the development of technologies used in this research, was provided by the Hutchinson Center's Hartwell Innovation Fund.

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The above story is reprinted from materials provided by Fred Hutchinson Cancer Research Center.

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Journal Reference:

  1. Adam L. Hughes, Daniel E. Gottschling. An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature, 2012; DOI: 10.1038/nature11654

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/y5kyCEdwqp8/121121145404.htm

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jessicaalva66: Daily Tips for Business: Workplace Communication ...

Well, as an entrepreneur I used to laugh at people who wanted to come to work for my company and on their resume they put that they had a Business Communications Degree. I used to think that they studied business communications because it was an easy subject in school, one that you could learn without having to deal with too much math, perhaps even taking the easy way out. Nevertheless workplace communication is an essential tool, and without it your business will not operate efficiently, and you are bound to get your wires crossed more often than not.

Source: http://dailytipsforbusiness.blogspot.com/2012/11/workplace-communication_19.html

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